A complex choreography of cell movements shapes the vertebrate eye
Development, ISSN: 0950-1991, Vol: 139, Issue: 2, Page: 359-372
2012
- 108Citations
- 173Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations108
- Citation Indexes108
- 108
- CrossRef77
- Captures173
- Readers173
- 173
Article Description
Optic cup morphogenesis (OCM) generates the basic structure of the vertebrate eye. Although it is commonly depicted as a series of epithelial sheet folding events, this does not represent an empirically supported model. Here, we combine four-dimensional imaging with custom cell tracking software and photoactivatable fluorophore labeling to determine the cellular dynamics underlying OCM in zebrafish. Although cell division contributes to growth, we find it dispensable for eye formation. OCM depends instead on a complex set of cell movements coordinated between the prospective neural retina, retinal pigmented epithelium (RPE) and lens. Optic vesicle evagination persists for longer than expected; cells move in a pinwheel pattern during optic vesicle elongation and retinal precursors involute around the rim of the invaginating optic cup. We identify unanticipated movements, particularly of central and peripheral retina, RPE and lens. From cell tracking data, we generate retina, RPE and lens subdomain fate maps, which reveal novel adjacencies that might determine corresponding developmental signaling events. Finally, we find that similar movements also occur during chick eye morphogenesis, suggesting that the underlying choreography is conserved among vertebrates. © 2012. Published by The Company of Biologists Ltd.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=83755225218&origin=inward; http://dx.doi.org/10.1242/dev.071407; http://www.ncbi.nlm.nih.gov/pubmed/22186726; https://journals.biologists.com/dev/article/139/2/359/45415/A-complex-choreography-of-cell-movements-shapes; https://dx.doi.org/10.1242/dev.071407; https://dev.biologists.org/content/139/2/359; http://dev.biologists.org/cgi/doi/10.1242/dev.071407; http://dev.biologists.org/content/139/2/359; http://dev.biologists.org/content/139/2/359.abstract; http://dev.biologists.org/content/139/2/359.full.pdf; https://dev.biologists.org/content/139/2/359.abstract; https://dev.biologists.org/content/develop/139/2/359.full.pdf; http://dev.biologists.org/lookup/doi/10.1242/dev.071407; http://f1000.com/13441967#eval14816062; http://f1000.com/13441967#eval15147059
The Company of Biologists
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