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Cardiorespiratory Fitness and Risk of Fatty Liver: The Young Finns Study

Medicine and Science in Sports and Exercise, ISSN: 1530-0315, Vol: 49, Issue: 9, Page: 1834-1841
2017
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Keeping your heart fit can prevent a fatty liver

Researchers say that cardiorespiratory fitness can lower the risk of fatty liver. The liver is a vital organ for good health. Fatty liver disease can

Article Description

Purpose Fatty liver is an expanding health concern associated with metabolic disturbances and increased risk of cardiovascular disease. Experimental studies in animals have shown associations between fatty liver and cardiorespiratory fitness but limited data exist in humans. The aim of this study was to analyze the links between cardiorespiratory fitness and fatty liver in a population-based sample of adults. Methods Participants were 463 adults (48% men) from the Cardiovascular Risk in Young Finns Study. Cardiorespiratory fitness was measured with a cycle ergometer exercise test as peak oxygen uptake (VO [mL·kg·min]) in 2008 to 2009. Hepatic ultrasonographic imaging was performed in 2011 to determine fatty liver. Results Cardiorespiratory fitness was associated with lower risk of fatty liver (1 mL·kg·min increase in VO: risk ratio, 0.90; 95% confidence interval, 0.88-0.93, P < 0.0001; adjusted for age and sex). This association remained significant after further adjustments with physical activity, adiposity, smoking, alcohol consumption, serum lipids, insulin, glucose, and C-reactive protein. Participants who were obese (waist circumference, >80 cm in women and >94 cm in men) but fit (VO in the upper age- and sex-specific median) had lower prevalence of fatty liver than participants who were obese and unfit (below median), (11.7% vs 34.8%, P = 0.0003). Conclusions In a population-based sample of adults, cardiorespiratory fitness is strongly, inversely and independently related with the risk of fatty liver. Importantly, the association is evident also among obese.

Bibliographic Details

Pälve, Kristiina S; Pahkala, Katja; Suomela, Emmi; Aatola, Heikki; Hulkkonen, Janne; Juonala, Markus; Lehtimäki, Terho; Rönnemaa, Tapani; Viikari, Jorma S A; Kähönen, Mika; Hutri-Kähönen, Nina; Telama, Risto; Tammelin, Tuija; Raitakari, Olli T

Ovid Technologies (Wolters Kluwer Health)

Medicine; Health Professions

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