Renal tubular acidosis in renal transplant patients: The effect of immunosuppressive drugs
Annals of Transplantation, ISSN: 1425-9524, Vol: 20, Page: 85-91
2015
- 10Citations
- 22Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations10
- Citation Indexes10
- 10
- CrossRef2
- Captures22
- Readers22
- 22
Article Description
Background: Renal tubular acidosis (RTA) is a non-anion gap metabolic acidosis and is generally mild and asymptomatic in kidney recipients. Calcineurine inhibitors (CNIs) increase the frequency of RTA but the frequency of RTA development in kidney transplant recipients receiving mammalian target of rapamycin inhibitors (mTORi) treatment remains unclear. In this study, we aimed to investigate the frequency of RTA in kidney transplant recipients on mTORi and CNI treatment and to compare both groups. Material/Methods: We enrolled 137 adult renal transplant patients – 82 patients on mTORi and 55 patients on CNI who had similar age, sex, posttransplant follow-up period, and graft functions. We recorded the parameters of venous blood gas analysis, including serum pH value, serum bicarbonate (HCO3) concentration, presence of metabolic aci-dosis defned as low HCO3 (<22 mEq/L), and serum pH value (<7.35), as well as base excess and urine pH at last follow-up. RTA was defned to be metabolic acidosis with normal serum anion gap and positive urine an-ion gap. Results: The mean age of our study population was 41.2±11.3 years. RTA frequency was 35% in the mTORi group and 41% in the CNI group. mTORi and CNI groups did not differ significantly in terms of the development of metabolic and renal tubular acidosis. Type I RTA was common in both groups. RTA was affected by duration of time since transplantation and graft functions in both groups. Conclusions: The rates of RTA development in patients on long-term CNI and mTORi treatment were similar.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84922570161&origin=inward; http://dx.doi.org/10.12659/aot.892320; http://www.ncbi.nlm.nih.gov/pubmed/25659354; http://www.annalsoftransplantation.com/abstract/index/idArt/892320; https://dx.doi.org/10.12659/aot.892320; https://www.annalsoftransplantation.com/abstract/index/idArt/892320
International Scientific Information, Inc.
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