Decreased level of albumin in peripheral blood mononuclear cells of streptozotocin-induced diabetic rats
Journal of Veterinary Medical Science, ISSN: 1347-7439, Vol: 76, Issue: 8, Page: 1087-1092
2014
- 17Citations
- 21Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef11
- Captures21
- Readers21
- 21
Article Description
We investigated the phenotypic level of albumin in peripheral blood mononuclear cells (PBMC) of streptozotocin (STZ)-induced diabetic rats. A specific reduction of albumin was identified by 2-dimensional electrophoresis and mass spectrometry. Decreased albumin content was also confirmed by immunoblotting and quantitative real-time PCR. Since albumin is a major and predominant antioxidant in plasma, the PBMC albumin may also contribute to their antioxidant activity. By measuring the amount of HO , lipid peroxidation and the redox form of glutathione, it was found that the production of the oxidative stress was elevated in STZ-diabetic rats compared to that of normal control. We suggest, therefore, that decreased albumin content may lead to the decreased antioxidant activity in the PBMC of type 1 diabetic rats.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84906849698&origin=inward; http://dx.doi.org/10.1292/jvms.13-0631; http://www.ncbi.nlm.nih.gov/pubmed/24758836; https://www.jstage.jst.go.jp/article/jvms/76/8/76_13-0631/_article; https://www.jstage.jst.go.jp/article/jvms/76/8/76_13-0631/_article/-char/en/; https://www.jstage.jst.go.jp/article/jvms/76/8/76_13-0631/_article/-char/ja/; https://dx.doi.org/10.1292/jvms.13-0631
Japanese Society of Veterinary Science
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