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A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo

PLoS ONE, ISSN: 1932-6203, Vol: 7, Issue: 2, Page: e32094
2012
  • 102
    Citations
  • 0
    Usage
  • 122
    Captures
  • 0
    Mentions
  • 10
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    102
  • Captures
    122
  • Social Media
    10
    • Shares, Likes & Comments
      10
      • Facebook
        10

Article Description

Dietary factors regulate immunological function, but the underlying mechanisms remain elusive. Here we show that vitamin B9 is a survival factor for regulatory T (Treg) cells expressing high levels of vitamin B9 receptor (folate receptor 4). In vitamin B9-reduced condition in vitro, Treg cells could be differentiated from naïve T cells but failed to survive. The impaired survival of Treg cells was associated with decreased expression of anti-apoptotic Bcl2 and independent of IL-2. In vivo depletion of dietary vitamin B9 resulted in the reduction of Treg cells in the small intestine, a site for the absorption of dietary vitamin B9. These findings provide a new link between diet and the immune system, which could maintain the immunological homeostasis in the intestine. © 2012 Kunisawa et al.

Bibliographic Details

http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84857419586&origin=inward; http://dx.doi.org/10.1371/journal.pone.0032094; http://www.ncbi.nlm.nih.gov/pubmed/22363800; https://dx.plos.org/10.1371/journal.pone.0032094.g002; http://dx.doi.org/10.1371/journal.pone.0032094.g002; https://dx.plos.org/10.1371/journal.pone.0032094.g005; http://dx.doi.org/10.1371/journal.pone.0032094.g005; https://dx.plos.org/10.1371/journal.pone.0032094; https://dx.plos.org/10.1371/journal.pone.0032094.g003; http://dx.doi.org/10.1371/journal.pone.0032094.g003; https://dx.plos.org/10.1371/journal.pone.0032094.g004; http://dx.doi.org/10.1371/journal.pone.0032094.g004; https://dx.plos.org/10.1371/journal.pone.0032094.g001; http://dx.doi.org/10.1371/journal.pone.0032094.g001; https://dx.doi.org/10.1371/journal.pone.0032094.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0032094.g002; https://dx.doi.org/10.1371/journal.pone.0032094.g004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0032094.g004; https://dx.doi.org/10.1371/journal.pone.0032094.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0032094.g001; https://dx.doi.org/10.1371/journal.pone.0032094.g005; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0032094.g005; https://dx.doi.org/10.1371/journal.pone.0032094; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032094; https://dx.doi.org/10.1371/journal.pone.0032094.g003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0032094.g003; http://dx.plos.org/10.1371/journal.pone.0032094.g002; http://dx.plos.org/10.1371/journal.pone.0032094.g005; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032094; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032094&type=printable; http://dx.plos.org/10.1371/journal.pone.0032094.g003; http://dx.plos.org/10.1371/journal.pone.0032094; http://dx.plos.org/10.1371/journal.pone.0032094.g004; http://dx.plos.org/10.1371/journal.pone.0032094.g001; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0032094; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0032094; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0032094&type=printable

Jun Kunisawa; Eri Hashimoto; Izumi Ishikawa; Hiroshi Kiyono; Jacques Zimmer

Public Library of Science (PLoS)

Multidisciplinary

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