A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo
PLoS ONE, ISSN: 1932-6203, Vol: 7, Issue: 2, Page: e32094
2012
- 102Citations
- 122Captures
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Metrics Details
- Citations102
- Citation Indexes102
- 102
- CrossRef78
- Captures122
- Readers122
- 122
Article Description
Dietary factors regulate immunological function, but the underlying mechanisms remain elusive. Here we show that vitamin B9 is a survival factor for regulatory T (Treg) cells expressing high levels of vitamin B9 receptor (folate receptor 4). In vitamin B9-reduced condition in vitro, Treg cells could be differentiated from naïve T cells but failed to survive. The impaired survival of Treg cells was associated with decreased expression of anti-apoptotic Bcl2 and independent of IL-2. In vivo depletion of dietary vitamin B9 resulted in the reduction of Treg cells in the small intestine, a site for the absorption of dietary vitamin B9. These findings provide a new link between diet and the immune system, which could maintain the immunological homeostasis in the intestine. © 2012 Kunisawa et al.
Bibliographic Details
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