High-fidelity tissue engineering of patient-specific auricles for reconstruction of pediatric microtia and other auricular deformities.

Citation data:

PloS one, ISSN: 1932-6203, Vol: 8, Issue: 2, Page: e56506

Publication Year:
2013
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Repository URL:
http://d-scholarship.pitt.edu/id/eprint/17870
PMID:
23437148
DOI:
10.1371/journal.pone.0056506; 10.1371/journal.pone.0056506.g001; 10.1371/journal.pone.0056506.g007; 10.1371/journal.pone.0056506.g004; 10.1371/journal.pone.0056506.g002; 10.1371/journal.pone.0056506.g006; 10.1371/journal.pone.0056506.g003; 10.1371/journal.pone.0056506.g008; 10.1371/journal.pone.0056506.g005
Pitt D-Scholarship Id:
17870
PMCID:
PMC3577892; 3577892
Author(s):
Alyssa J. Reiffel; Concepcion Kafka; Karina A. Hernandez; Samantha Popa; Justin L. Perez; Sherry Zhou; Satadru Pramanik; Bryan N. Brown; Won Seuk Ryu; Lawrence J. Bonassar; Jason A. Spector; Xiaoming He Show More Hide
Publisher(s):
Public Library of Science (PLoS); Figshare
Tags:
Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine; Biotechnology; modulus; hydraulic; permeability; tissue-engineered; bovine; auricular; surgery; biotechnology; pediatrics and child health; width; staining; specimens; harvested; specimen; 1-month; 3-month; samples; safranin; verhoeff; via:twitter
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article description
Autologous techniques for the reconstruction of pediatric microtia often result in suboptimal aesthetic outcomes and morbidity at the costal cartilage donor site. We therefore sought to combine digital photogrammetry with CAD/CAM techniques to develop collagen type I hydrogel scaffolds and their respective molds that would precisely mimic the normal anatomy of the patient-specific external ear as well as recapitulate the complex biomechanical properties of native auricular elastic cartilage while avoiding the morbidity of traditional autologous reconstructions.