Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns.

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PloS one, ISSN: 1932-6203, Vol: 12, Issue: 2, Page: e0172980

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10.1371/journal.pone.0172980; 10.1371/journal.pone.0172980.g001; 10.1371/journal.pone.0172980.g002
Paul S. Stadem; Megan V. Hilgers; Derrick Bengo; Sarah E. Cusick; Susan Ndidde; Tina M. Slusher; Troy C. Lund; Vasu D. Appanna
Public Library of Science (PLoS); Figshare
Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Biochemistry; Medicine; Cell Biology; Genetics; Molecular Biology; Neuroscience; Biotechnology; Chemical Sciences not elsewhere classified; Biological Sciences not elsewhere classified; Developmental Biology; Mental Health; G 6PD; G 6PD deficiency; 202A; umbilical cord blood; baseline oxidative stress; molecule antioxidant capacity; oxidative stress; African newborns Glucose -6-phosphate dehydrogenase; 69999 Biological Sciences not elsewhere classified; 39999 Chemical Sciences not elsewhere classified; g 6pd; g 6pd deficiency; 202a; african newborns glucose -6-phosphate dehydrogenase
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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disorder that affects as many as 400 million people worldwide, making it the most common enzymatic defect. Subjects with G6PD deficiency are more likely to develop neonatal hyperbilirubinemia potentially leading to kernicterus and are at increased risk for acute hemolytic anemia when exposed to pro-oxidant compounds such as anti-malarial drugs. We collected umbilical cord blood from 300 males born in Uganda to assess for novel markers of systemic oxidative stress. We determined that 10.7% of the samples collected were G6PD A- deficient (G202A/A376G) and when these were compared with unaffected controls, there was significantly higher 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentration, elevated ferritin, increased leukocyte count and higher small molecule antioxidant capacity. These data suggest increased baseline oxidative stress and an elevated antioxidant response in umbilical cord blood of patients with G6PD deficiency.