Acridine orange fluorescent microscopy is more sensitive than India ink light microscopy in the rapid detection of cryptococcosis among CrAg positive HIV patients.

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PloS one, ISSN: 1932-6203, Vol: 12, Issue: 7, Page: e0182108

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Richard Kwizera; Andrew Akampurira; Darlisha Williams; David R. Boulware; David B. Meya; On Behalf Of The Astro Cm Study Team
Public Library of Science (PLoS)
Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences
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India ink microscopy on cerebrospinal fluid is still utilized in resource limited settings for the diagnosis of cryptococcal meningitis despite its poor sensitivity. We hypothesized that staining fungal nucleic acids with fluorescent dyes instead of the capsule with India ink might improve sensitivity for the diagnosis of cryptococcal meningitis.