Parvalbumin-positive inhibitory interneurons oppose propagation but favor generation of focal epileptiform activity
Journal of Neuroscience, ISSN: 1529-2401, Vol: 35, Issue: 26, Page: 9544-9557
2015
- 112Citations
- 251Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations112
- Citation Indexes112
- 112
- CrossRef79
- Captures251
- Readers251
- 251
Article Description
Parvalbumin (Pv)-positive inhibitory interneurons effectively control network excitability, and their optogenetic activation has been reported to block epileptic seizures. An intense activity in GABAergic interneurons, including Pv interneurons, before seizures has been described in different experimental models of epilepsy, raising the hypothesis that an increased GABAergic inhibitory signal may, under certain conditions, initiate seizures. It is therefore unclear whether the activity of Pv interneurons enhances or opposes epileptiform activities. Here we use a mouse cortical slice model of focal epilepsy in which the epileptogenic focus can be identified and the role of Pv interneurons in the generation and propagation of seizure-like ictal events is accurately analyzed by a combination of optogenetic, electrophysiological, and imaging techniques. We found that a selective activation of Pv interneurons at the focus failed to block ictal generation and induced postinhibitory rebound spiking in pyramidal neurons, enhancing neuronal synchrony and promoting ictal generation. In contrast, a selective activation of Pv interneurons distant from the focus blocked ictal propagation and shortened ictal duration at the focus. We revealed that the reduced ictal duration was a direct consequence of the ictal propagation block, probably by preventing newly generated afterdischarges to travel backwards to the original focus of ictal initiation. Similar results were obtained upon individual Pv interneuron activation by intracellular depolarizing current pulses. The functional dichotomy of Pv interneurons here described opens new perspectives to our understanding of how local inhibitory circuits govern generation and spread of focal epileptiform activities.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84936139063&origin=inward; http://dx.doi.org/10.1523/jneurosci.5117-14.2015; http://www.ncbi.nlm.nih.gov/pubmed/26134638; http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.5117-14.2015; https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.5117-14.2015; https://dx.doi.org/10.1523/jneurosci.5117-14.2015; https://www.jneurosci.org/content/35/26/9544
Society for Neuroscience
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