Neurochemical Predictors of Generalized Learning Induced by Brain Stimulation and Training
Journal of Neuroscience, ISSN: 1529-2401, Vol: 44, Issue: 21
2024
- 1Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Methods of cognitive enhancement for humans are most impactful when they generalize across tasks. However, the extent to which such "transfer"is possible via interventions is widely debated. In addition, the contribution of excitatory and inhibitory processes to such transfer is unknown. Here, in a large-scale neuroimaging individual differences study with humans (both sexes), we paired multitasking training and noninvasive brain stimulation (transcranial direct current stimulation, tDCS) over multiple days and assessed performance across a range of paradigms. In addition, we varied tDCS dosage (1.0 and 2.0 mA), electrode montage (left or right prefrontal regions), and training task (multitasking vs a control task) and assessed GABA and glutamate concentrations via ultrahigh field 7T magnetic resonance spectroscopy. Generalized benefits were observed in spatial attention, indexed by visual search performance, when multitasking training was combined with 1.0 mA stimulation targeting either the left or right prefrontal cortex (PFC). This transfer effect persisted for ~30 d post intervention. Critically, the transferred benefits associated with right prefrontal tDCS were predicted by pretraining concentrations of glutamate in the PFC. Thus, the effects of this combined stimulation and training protocol appear to be linked predominantly to excitatory brain processes.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85193935765&origin=inward; http://dx.doi.org/10.1523/jneurosci.1676-23.2024; http://www.ncbi.nlm.nih.gov/pubmed/38531634; https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1676-23.2024; https://dx.doi.org/10.1523/jneurosci.1676-23.2024; https://www.jneurosci.org/content/44/21/e1676232024
Society for Neuroscience
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