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Is childhood vaccination associated with asthma? A meta-analysis of observational studies

Pediatrics, ISSN: 0031-4005, Vol: 120, Issue: 5, Page: e1269-77
2007
  • 46
    Citations
  • 0
    Usage
  • 44
    Captures
  • 0
    Mentions
  • 32
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    46
  • Captures
    44
  • Social Media
    32
    • Shares, Likes & Comments
      32
      • Facebook
        32

Article Description

BACKGROUND. The possible link between immunization and atopic diseases has been under intense debate in the last decade. OBJECTIVE. The aim of this study was to systematically review the available evidence on the association of whole-cell pertussis and BCG vaccination with the risk of asthma in childhood and adolescence. METHODS. The major medical electronic databases (Medline, National Library of Medicine Gateway, and Cochrane Library) were searched, and reference lists of the relevant publications were reviewed for relevant birth-cohort studies and randomized, controlled trials from 1966 to March 2006. Only studies that directly compared vaccinated and unvaccinated children, validated vaccination status by medical charts, and used preset criteria to define asthma were included. Data were abstracted by using a standardized protocol and computerized report form. Results were analyzed by applying a fixed-effect or random-effect model, according to the heterogeneity of the studies. Sensitivity analyses by scoring criteria were performed. RESULTS. Seven studies of pertussis vaccination (with a total of 186 663 patients) and 5 studies of BCG vaccination (with a total of 41 479 patients) met our inclusion criteria. No statistically significant association was detected between either whole-cell pertussis or BCG vaccination and incidence rates of asthma during childhood and adolescence. This lack of a significant association proved to be robust on sensitivity analyses for BCG but not for pertussis vaccine. CONCLUSIONS. Currently available data, based on observational studies, do not support an association, provocative or protective, between receipt of the BCG or whole-cell pertussis vaccine and risk of asthma in childhood and adolescence. Copyright © 2007 by the American Academy of Pediatrics.

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