Fatal Myocarditis Associated With HHV-6 Following Immunosuppression in Two Children.

Citation data:

Pediatrics, ISSN: 1098-4275, Vol: 137, Issue: 1, Page: e20151352

Publication Year:
2016
Usage 6
Abstract Views 5
Link-outs 1
Citations 3
Citation Indexes 3
PMID:
26681781
DOI:
10.1542/peds.2015-1352
Author(s):
Stefanski, Heather E, Thibert, Kathryn A, Pritchett, Joshua, Prusty, Bhupesh K, Wagner, John E, Lund, Troy C
Publisher(s):
American Academy of Pediatrics (AAP)
Tags:
Medicine
article description
Fatal myocarditis is a rare complication in immunosuppressed children. Recent reports have linked human herpesvirus 6 (HHV-6) infection, typically a benign infection in childhood, with myocarditis. HHV-6 can reactivate during periods of immunosuppression. Here, we report 2 cases in which children were immunosuppressed, one for treatment of Evans syndrome and the other post hematopoietic stem cell transplantation, who developed rapid and fatal HHV-6-associated myocarditis. These cases suggest that HHV-6 infection should be considered as an etiology of myocarditis in immunosuppressed patients regardless of correlating blood levels. Early treatment of HHV-6 in patients with myocarditis could improve morbidity and mortality.

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