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The experimental granuloma. A hypothesis to explain the persistence of the lesion.

Revista do Instituto de Medicina Tropical de São Paulo, ISSN: 0036-4665, Vol: 37, Issue: 2, Page: 161-176
1995
  • 43
    Citations
  • 8,276
    Usage
  • 11
    Captures
  • 0
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    43
  • Usage
    8,276
    • Full Text Views
      7,000
    • Abstract Views
      1,276
  • Captures
    11
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Review Description

Granulomatous inflammation is the morphological substrate of a variety of important infectious diseases such as tuberculosis, leprosy, schistosomiasis and others. Nevertheless, although many aspects of this special type of inflammation are known, fundamental questions concerning granuloma formation, persistence, fate and significance for host-parasite relationships still remain to be elucidated. In this brief review, the basic and more relevant literature related to experimental investigations on granuloma physiopathology is presented. Based on recent investigations performed in our laboratory showing that MDF (Macrophage Deactivating Factor) secreted by epithelioid cells and characterized as the calcium-binding protein protein MRP-14 deactivates activated macrophages, a hypothesis to explain the persistence of granulomatous inflammation is put forward.

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