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Hydrogen sulfide inhibits plasma renin activity

Journal of the American Society of Nephrology, ISSN: 1533-3450, Vol: 21, Issue: 6, Page: 993-1002
2010
  • 156
    Citations
  • 0
    Usage
  • 49
    Captures
  • 0
    Mentions
  • 29
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    156
  • Captures
    49
  • Social Media
    29
    • Shares, Likes & Comments
      29
      • Facebook
        29

Article Description

The development of renovascular hypertension depends on the release of renin from the juxtaglomerular (JG) cells, a process regulated by intracellular cAMP. Hydrogen sulfide (HS) downregulates cAMP production in some cell types by inhibiting adenylyl cyclase, suggesting the possibility that it may modulate renin release. Here, we investigated the effect of HS on plasma renin activity and BP in rat models of renovascular hypertension. In the two-kidney-one-clip (2K1C) model of renovascular hypertension, the H S donor NaHS prevented and treated hypertension. Compared with vehicle, NaHS significantly attenuated the elevation in plasma renin activity and angiotensin II levels but did not affect plasma angiotensin-converting enzyme activity. Furthermore, NaHS inhibited the upregulation of renin mRNA and protein levels in the clipped kidneys of 2K1C rats. In primary cultures of renin-rich kidney cells, NaHS markedly suppressed forskolin-stimulated renin activity in the medium and the intracellular increase in cAMP. In contrast, NaHS did not affect BP or plasma renin activity in normal or one-kidney-one-clip (1K1C) rats, both of which had normal plasma renin activity. In conclusion, these results demonstrate that HS may inhibit renin activity by decreasing the synthesis and release of renin, suggesting its potential therapeutic value for renovascular hypertension. Copyright © 2010 by the American Society of Nephrology.

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