Ghrelin Exerts Analgesic Effects through Modulation of IL-10 and TGF-β Levels in a Rat Model of Inflammatory Pain.

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Iranian biomedical journal, ISSN: 2008-823X, Vol: 21, Issue: 2, Page: 114-9

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Azizzadeh, Faranak; Mahmoodi, Javad; Sadigh-Eteghad, Saeed; Farajdokht, Fereshteh; Mohaddes, Gisou
CASRP: Center of Advanced Scientific Research and Publications
Biochemistry, Genetics and Molecular Biology; Medicine
article description
Ghrelin is a peptide with attenuating effect on inflammatory pain. Both anti- and pro-inflammatory mediators have a role in the nociception and development of pain and hyperalgesia. IL-10 and TGF-β are anti-inflammatory cytokines and inhibit the expression of pro-inflammatory cytokines related to peripheral and central inflammatory pain. In this study, the effects of i.p. injection of ghrelin on the early and the late phases of pain, as well as serum levels of IL-10 and TGF-β, as anti-inflammatory cytokines, were investigated in formalin-induced pain in male rats.