Correlation Between Cannabidiol-Induced Reduction of Infarct Volume and Inflammatory Factors Expression in Ischemic Stroke Model.

Citation data:

Basic and clinical neuroscience, ISSN: 2008-126X, Vol: 8, Issue: 2, Page: 139-146

Publication Year:
2017
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PMID:
28539998
DOI:
10.18869/nirp.bcn.8.2.139
Author(s):
Khaksar, Sepideh; Bigdeli, Mohammad Reza
Publisher(s):
CASRP: Center of Advanced Scientific Research and Publications
article description
Recent studies demonstrated that cannabidiol had neuroprotective property. There is some evidence about effective role of cannabidiol in reduction of ischemic damages. It has been reported that infarct size is influenced by various factors after MCAO, including inflammatory factors. The aim of the present study was to evaluate the effect of cannabidiol on infarction volume and correlation of infarct size with tumor necrosis factor receptor 1 (TNFR1), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) expression.