A Surface-Enhanced Raman Scattering Aptasensor for Escherichia Coli Detection Based on High-Performance 3D Substrate And Hot Spot Effect
SSRN Electronic Journal
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
A surface-enhanced Raman scattering (SERS) aptasensor was established for highly sensitive and specific detection of Escherichia coli (E. coli), which based on high-performance SERS 3D substrate and hot spot effect. Chitosan hydrogel (CS gel) modified with E. coli aptamer (Apt) functionalized silver nanoparticles (Apt-AgNPs-CS gel) were constructed as a high-performance SERS 3D substrate for specific bacteria enrichment, while the Raman signaling molecule 4-MBA and E. coli Apt modified gold nanostar (GNS@4-MBA-Apt NPs) were synthesized based on hot spot effect for the sensitive quantification of E. coli. Due to the huge SERS enhancement based on hot spot effect and the specific recognition ability of Apt, a detection limit of 3.46 CFU/mL with a wide dynamic linear range from 3.2×101 to 3.2×107 CFU/mL (R2 =0.99875) could be achieved without other non-target bacteria interference. Moreover, this SERS aptasensor was applied to detect E. coli in actual samples with good recovery rate. In addition, this SERS strategy can be extended to the detection of other targets by replacing the corresponding Apts. Hence our SERS aptasensor has potential application in food safety and environmental pollution monitoring.
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