PlumX Metrics
Embed PlumX Metrics

Association between Pyrethroids Exposure and Risk of Depressive Symptoms in U.S. Adults

SSRN, ISSN: 1556-5068
2022
  • 0
    Citations
  • 168
    Usage
  • 1
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Pyrethroids-containing products are widely used in people’s daily life. The general population is exposed to pyrethroids in the U.S. and worldwide. Pyrethroids are a class of neurotoxicants that can cause neurotoxic impairments in humans. Researches on the effects of exposure to pyrethroids on depressive symptoms are scare. Therefore, this study aims to investigate the association between pyrethroids exposure and risk of depressive symptoms in U.S. adults. Data of participants aged ≥20 years (n=6339) from the National Health and Nutrition Examination Survey (NHANES, 2007-2014) were included. 3-phenoxybenzoic acid (3-PBA), an adequately detected pyrethroids metabolite, was used as a biomarker to assess pyrethroids exposure. Depressive symptoms were defined as a total score of 10 or above. Multivariate logistic regression analyses were performed to examine the association of urinary 3-PBA with risk of depressive symptoms. In this study, 607 individuals (9.6%) of all participants were shown to develop depressive symptoms. The weighted geometric mean of uncorrected and creatinine-corrected urinary 3-PBA concentrations were 0.53μg/L (95%CI: 0.50, 0.56), 0.56μg/g (95%CI: 0.53, 0.60) respectively. Compared with those in the lowest quartile of urinary 3-PBA, individuals in the highest quartile have a higher risk of depressive symptoms after adjustment for all covariates (OR: 1.13; 95%CI: 0.85, 1.49). The results persisted in sensitivity analyses. Restricted cubic spline showed a nonlinear positive association between urinary 3-PBA and depressive symptoms (P = 0.014). Subgroup analysis showed the association between urinary 3-PBA and depressive symptoms was significant in participants with hypertension, but not in those without hypertension (1.18 vs 0.99, P for interaction = 0.04). Our study indicated that pyrethroids exposure in the general U.S. population has increased over time and that pyrethroids exposure may increase the risk of depressive symptoms.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know