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Hippocampal and Medial Prefrontal Cortical Maps Represent Episodes and Rules in a Common Task Space

SSRN Electronic Journal
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Article Description

Memory helps us adapt to changing circumstances but needs guidance to retrieve relevant episodes. Episodic memory requires the hippocampus, the prefrontal cortex (PFC) guides memory retrieval, but how their representations interact is unclear. We found CA1 and PFC activity within and between rats formed similar, low-dimensional, region-specific “shapes” representing different tasks tested in the same maze. Task shapes were organized by behaviorally salient variables including time and maze location. PFC predicted CA1 representations when both regions were needed to solve a spatial memory task, but not in a cue approach task that required neither region. Task demands imposed common dimensions on CA1 and PFC maps whose topologies distinguished episodic and rule-related computations. Funding Information: This work was supported by the National Institutes of Health (NIMH 2R01MH073689, NIMH MH118297, and NIMH MH119523 to M.L.S.) and the NVIDIA corporation. Declaration of Interests: The authors report no conflicts of interest.

Bibliographic Details

Aditya Srinivasan; Justin Samuel Riceberg; Michael R. Goodman; Arvind Srinivasan; Kevin G. Guise; Matthew Shapiro

Elsevier BV

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