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Perioperative management after elective cardiac surgery: The predictive value of procalcitonin for infective and noninfective complications

Future Cardiology, ISSN: 1744-8298, Vol: 17, Issue: 8, Page: 1349-1358
2021
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Procalcitonin for the diagnosis of postoperative bacterial infection after adult cardiac surgery: a systematic review and meta-analysis

Davide Nicolotti 1, Silvia Grossi 1, Valeria Palermo 1, Federico Pontone 1, Giuseppe Maglietta 2, Francesca Diodati 2, Matteo Puntoni 2, Sandra Rossi 1 na1 &

Article Description

Objective: Procalcitonin (PCT) has been associated with adverse outcomes after cardiac surgery. Nevertheless, there is no consensus on thresholds and timing of PCT measurement to predict adverse outcomes. Materials & methods: A total of 960 patients undergoing elective cardiac surgery were retrospectively evaluated. PCT levels were measured from the first to the seventh postoperative day (POD). The onset of complications was recorded. Results: Complications occurred in 421 (44%) patients. PCT on the third POD was associated with the occurrence of any kind of complications (odds ratio: 1.06; p: 0.037), and noninfectious complications (odds ratio: 1.05; p: 0.035), after adjusting. PCT above the median value at the third POD (>0.33 μg/l) predicted postoperative complications (incidence rate ratio: 1.13; p = 0.035). Conclusion: PCT seems to predict postoperative complications in cardiac surgery. The determination at the third POD yields the greatest sensitivity and specificity.

Bibliographic Details

Laudisio, Alice; Nenna, Antonio; Musarò, Marta; Angeletti, Silvia; Nappi, Francesco; Lusini, Mario; Chello, Massimo; Incalzi, Raffaele Antonelli

Informa UK Limited

Biochemistry, Genetics and Molecular Biology; Medicine

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