Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes
Diabetes Care, ISSN: 0149-5992, Vol: 30, Issue: 3, Page: 649-654
2007
- 97Citations
- 54Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations97
- Citation Indexes97
- 97
- CrossRef67
- Captures54
- Readers54
- 54
Article Description
OBJECTIVE - Previous studies have shown that in type 1 diabetes endothelial dysfunction persists even when glycemia is normalized. Moreover, oxidative stress has recently been demonstrated to be the mediator of hyperglycemia- induced endothelial dysfunction. RESEARCH DESIGN AND METHODS - Thirty-six type 1 diabetic patients and 12 control subjects were enrolled. The diabetic patients were divided into three groups. The first group was treated for 24 h with insulin, achieving a near-normalization of glycemia. After 12 h of this treatment, vitamin C was added for the remaining 12 h. The second group was treated for 24 h with vitamin C. After 12 h of this treatment, insulin was started, with achievement of near-normalization of glycemia for the remaining 12 h. The third group was treated for 24 h with both vitamin C and insulin, achieving near-normalization of glycemia. RESULTS - Neither normalization of glycemia nor vitamin C treatment alone was able to normalize endothelial dysfunction or oxidative stress. However, a combination of insulin and vitamin C normalized endothelial dysfunction and decreased oxidative stress to normal levels. CONCLUSIONS - This study suggests that long-lasting hyperglycemia in type 1 diabetic patients induces permanent alterations in endothelial cells, which may contribute to endothelial dysfunction by increased oxidative stress even when hyperglycemia is normalized. © 2007 by the American Diabetes Association.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33847612960&origin=inward; http://dx.doi.org/10.2337/dc06-2048; http://www.ncbi.nlm.nih.gov/pubmed/17327335; https://diabetesjournals.org/care/article/30/3/649/25636/Simultaneous-Control-of-Hyperglycemia-and; https://dx.doi.org/10.2337/dc06-2048; https://care.diabetesjournals.org/content/30/3/649
American Diabetes Association
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