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Estimated Life-Years Gained Free of New or Recurrent Major Cardiovascular Events With the Addition of Semaglutide to Standard of Care in People With Type 2 Diabetes and High Cardiovascular Risk

Diabetes Care, ISSN: 1935-5548, Vol: 45, Issue: 5, Page: 1211-1218
2022
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Metric Options:   Counts1 Year3 Year

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Semaglutide use adds CVD-free life-years for high-risk adults with type 2 diabetes

Adults with type 2 diabetes at high risk for cardiovascular disease add 1.7 life-years free of CVD when prescribed semaglutide along with standard diabetes care, according to study findings published in Diabetes Care. “The addition of semaglutide to standard of care was associated with an important gain in life-years free of new and recurrent CVD events and a decrease in 10-year CVD risk,” Jan Wes

Article Description

OBJECTIVE Semaglutide, a glucagon-like peptide 1 receptor agonist, reduced major adverse cardiovascular events (MACE) in people with type 2 diabetes (T2D) at high risk of cardiovascular disease (CVD) in a post hoc analysis of pooled data from Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects With Type 2 Diabetes (SUSTAIN) 6 and Peptide Innovation for Early Diabetes Treatment (PIONEER) 6. We estimated the benefit of adding semaglutide to standard of care (SoC) on life-years free of new/recurrent CVD events in people with T2D at high risk of CVD. RESEARCH DESIGN AND METHODS The Diabetes Lifetime-perspective prediction (DIAL) competing risk–adjusted lifetime CVD risk model for people with T2D was developed previously. Baseline characteristics of the pooled cohort from SUSTAIN 6 and PIONEER 6 (POOLED cohort) (N = 6,480) were used to estimate individual life expectancy free of CVD for patients in the POOLED cohort. The hazard ratio of MACE from adding sema-glutide to SoC was derived from the POOLED cohort (hazard ratio [HR] 0.76 [95% CI 0.62–0.92]) and combined with an individual’s risk to estimate their CVD benefit. RESULTS Adding semaglutide to SoC was associated with a wide distribution in life-years free of CVD gained, with a mean increase of 1.7 (95% CI 0.5–2.9) life-years. Estimated life-years free of CVD gained with semaglutide was dependent on baseline risk (life-years free of CVD gained in individuals with established CVD vs. those with cardiovascular risk factors only: 2.0 vs. 0.2) and age at treatment initiation. CONCLUSIONS Adding semaglutide to SoC was associated with a gain in life-years free of CVD events that was dependent on baseline CVD risk and age at treatment initiation. This study helps contextualize the results of semaglutide clinical trials.

Bibliographic Details

Westerink, Jan; Matthiessen, Kasper Sommer; Nuhoho, Solomon; Fainberg, Udi; Lyng Wolden, Michael; Østergaard, Helena Bleken; Visseren, Frank; Sattar, Naveed

American Diabetes Association

Medicine; Nursing

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