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Biological time-related changes in tolerance of Male mice to hypoxia - II. Orcadian rhythm of lysosomal susceptibility to hypoxia

Chronobiology International, ISSN: 0742-0528, Vol: 1, Issue: 4, Page: 245-250
1984
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Circadian variations of mouse liver, brain and heart lysosomal susceptibility to hypoxia were investigated. Lysosomal disruption during hypoxia was estimated on the basis of the following measurements: changes in percentage free activity of βgalactosidase and acid phosphatase, tissue loss of both lysosomal enzymes and accumulation of serum βgalactosidase. When exposure to hypoxia took place at the end of the rest phase or at the beginning of the active phase, it was accompanied by maximum increase of percent free activity. This, presumably represents a diffusion of enzymes from lysosomes due to altered membrane permeability. However, hypoxia when occurring during the second part of the active phase and first part of the rest phase resulted in tissues loss of lysosomal enzymes and accumulation of serum lysosomal enzymes. This is believed to represent the release of lysosomal enzymes in bulk from damaged or ruptured lysosomal membranes. © 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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