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Myelomonocytic associated antigens in b-chronic lymphocytic leukemia: Analysis of clinical significance

Leukemia and Lymphoma, ISSN: 1042-8194, Vol: 5, Issue: 2-3, Page: 139-144
1991
  • 13
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  • 2
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Metrics Details

  • Citations
    13
    • Citation Indexes
      13
  • Captures
    2

Article Description

The expression of myelomonocytic (My+) associated antigens on lymphocytes from B-chronic lymphocytic leukemia (B-CLL) was studied in 62 patients. Most of them expressed at least a My antigen: CD11b in 40 cases (64.2%), CD13 in 31 (50%), CD14 in 18 (29%), CD33 in 41 (66%), CD36 in 6 (9.6%). The relationship between the clinical features of the disease and My antigen status was studied. No significant correlation was found between Rai's clinical stages and the average percent value of CD11b, CD13, CD33 and CD36. In contrast, patients in Rai's stage 0 had a significant lower value of CD14 positive cells than those with more advanced disease (P < 0.001). Interestingly, patients with a diffuse bone marrow histology had a higher average percent value of CD33-positive cells (76.3% ± 29.3) than those with a non-diffuse one (50.4% ± 37.5). Furthermore, 90% of My patients fulfilled Montserrat's criteria of "smouldering" CLL while only 48.3% of My cases did (P < 002). My lineage antigens on B-CLL cells may provide another criterion to characterize patient subgroups with a poor prognosis. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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