PlumX Metrics
Embed PlumX Metrics

Diagnostic approaches to acute promyelocytic leukaemia

Leukemia and Lymphoma, ISSN: 1042-8194, Vol: 33, Issue: 1-2, Page: 53-63
1999
  • 16
    Citations
  • 0
    Usage
  • 6
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    16
    • Citation Indexes
      15
    • Clinical Citations
      1
      • PubMed Guidelines
        1
  • Captures
    6

Review Description

Delivering the most effective clinical therapy in acute promyelocytic leukaemia (APL) is dependent on accurately making the diagnosis. The morphological diagnosis can be improved by detecting the presence of a specific chromosome translocation, the t(15;17)(q22;q21). This can be achieved using cytogenetics, RT-PCR, FISH and anti-PML monoclonal antibody. The optimal approach will be rapid, accurate and readily integrated into the routine haematology laboratory. Immunofluorescent detection of microparticulate PML protein fulfils these criteria, however, karyotyping will also detect the variant translocations and remains the 'gold-standard'.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know