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The effect of resveratrol on blood pressure in a rat model of preeclampsia

Journal of Maternal-Fetal and Neonatal Medicine, ISSN: 1476-7058, Vol: 25, Issue: 6, Page: 845-848
2012
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Article Description

Objective: To examine the hypothesis that resveratrol administration could result in blood pressure and blood flow decrease in a rat preeclampsia model. Materials and Methods: Desoxycorticosterone acetate (DOCA) was used to produce hypertension. The Wistar albino rats were divided randomly into three groups: control (n=12), DOCA injected (n=11), and DOCA injected and resveratrol treated (n=13). Rats were sacrificed on gestational day 16-20. The systolic blood pressure was measured by the tail-cuff method. Urine protein was expressed as protein/creatinine. Laser Doppler measurements of the blood flow were made in one placenta, the left kidney and both parietal lobes of brain. Placentas were examined by light microscopy. Results: DOCA injected group exhibited significant differences in blood pressure and protein/creatinine. Mean blood pressure in DOCA-treated rats was 130.1±12.9 mmHg at baseline and 148.4±20.1 mmHg at the time of euthanization (p=0.044). Resveratrol did not significantly affect blood pressure, placental and renal blood flows. There were also no significant differences in placental pathology parameters among the three groups. Conclusion: The present study demonstrated that resveratrol did not decrease blood pressure, and did not result in a significant response in blood flows and placental pathology parameters. © 2012 Informa UK, Ltd.

Bibliographic Details

Moraloglu, Ozlem; Engin-Ustun, Yaprak; Tonguç, Esra; Var, Turgut; Tapisiz, Omer Lütfü; Ergün, Hakan; Guvenc, Tolga; Gacar, Ayhan

Informa UK Limited

Medicine

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