PlumX Metrics
Embed PlumX Metrics

Ghrelin, acylated ghrelin, leptin and PYY-3 levels in hyperemesis gravidarum

Journal of Maternal-Fetal and Neonatal Medicine, ISSN: 1476-7058, Vol: 26, Issue: 9, Page: 866-870
2013
  • 10
    Citations
  • 0
    Usage
  • 17
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Objective: To assess the serum levels of gut and adipocyte-derived metabolic hormones that control appetite, adipocity, weight gain and energy hemostasis, namely total ghrelin (TG), acylated ghrelin (AG), leptin and PYY-3 in hyperemesis gravidarum (HG). Methods: Plasma samples of 86 women in their first trimester pregnancies with HG (n=30), morning sickness of pregnancy (MSP) (n=34) and control (n=22) groups were obtained. Serum levels of TG, AG, leptin and PYY-3 were compared between the groups, and the correlations with severity of symptoms using modified PUQE (Pregnancy Unique Quantification of Emesis) scoring, BMI, E2, hCG and TSH were calculated. Results: Levels of TG, AG, PYY-3 and the TG/leptin ratio were significantly higher in HG group compared to MSP and the control groups (p0.017). AG/TG ratio was significantly lower in the HG group compared to both MSP and control groups (p0.017). There were either weak or no significant statistical correlations between the gut and adipose-related hormones and the modified PUQE scores, BMI, E2, hCG and TSH. Conclusion: Gut-derived metabolic hormones ghrelin, AG and PYY-3 may be involved in the HG pathophysiology. © 2013 Informa UK Ltd All rights reserved.

Bibliographic Details

Albayrak, Mustafa; Karatas, Ahmet; Demiraran, Yavuz; Erman, Hayriye; Topuz, Seren; Bıyık, İsmail; Uzun, Hafize; Erkan, Muserref

Informa UK Limited

Medicine

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know