Preparation, characterization and ex vivo permeability study of transdermal apixaban O/W nanoemulsion based gel
Iraqi Journal of Pharmaceutical Sciences, ISSN: 2521-3512, Vol: 29, Issue: 2, Page: 214-222
2021
- 13Citations
- 30Captures
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Article Description
This study designed to prepare ultrafine apixaban (APX) o/w nanoemulsion (NE) based gel with droplet size below 50 nm as a good method for transdermal APX delivery without using permeation enhancer, alternatively, the formulation components itself act as permeation enhancer. APX, a potent oral anticoagulant drug that selectively and directly inhibit coagulation factor Xa, was selected as a good candidate for transdermal delivery as it displays poor water solubility (0.028 mg/mL) and low bioavailability (50%). APX-NE gel was prepared using triacetin, triton-x-100 and carbitol as oil phase, surfactant and cosurfactant respectively, while Carbopol 940 used as a gelling agent. Ex vivo permeation of APX-NE gel through human stratum corneum reveal significant (p ≤ 0.05) enhancement in permeation parameters (Jss, PC and Er, and shorter Tlag) in comparison with the prepared pure APX gel.
Bibliographic Details
College of Pharmacy University of Baghdad
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