GC-MS based metabolomics analysis and characterization of rosmarinic acid from tropical seagrass halodule pinifolia

Citation data:

International Journal of Pharmaceutical Research, ISSN: 0975-2366, Vol: 10, Issue: 4, Page: 277-285

Publication Year:
2018
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DOI:
10.31838/ijpr/2018.10.04.023
Author(s):
Jeyapragash Danaraj; Saravanakumar Ayyappan; Thangaradjou Thirunavukkarasu; Santosh Kumar; Sajeli Begum
Tags:
Pharmacology, Toxicology and Pharmaceutics
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article description
Study investigated the metabolomics analysis of seagrass for acquiring diverse group of metabolites which offers various prospects for novel, financially significant constituents conveyed to the spotlight. GC-MS analysis revealed the presence of thirty five compounds includes metabolites, flavonoids, sugars, aminoacids and plant hormones. Rosmarinic acid (RA) is a pharmacologically active phytoconstituent that has so far been reported on the family of Boraginaceae and Lamiaceae. Present finding records the presence of RA from tropical seagrass Halodule pinifolia of Cymodoceaceae family collected from vellar estuary and is the first report on a tropical seagrass distributed in India. The existence of RA was identified by co-TLC, HPLC-PDA-MS and further it was confirmed by isolation of RA through prep-TLC and structural characterisation via NMR analysis. Study has explored a newer marine source, H. pinifolia for RA, which has an emerging potential preclinical chemical entity and its biosynthesis can be enriched by plant tissue culture.