Combination of preoperative D-dimer and mean platelet volume predicts postoperative deep venous thrombosis in breast cancer patients
Cancer Biomarkers, ISSN: 1875-8592, Vol: 21, Issue: 4, Page: 909-913
2018
- 18Citations
- 15Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations18
- Citation Indexes18
- 18
- CrossRef15
- Captures15
- Readers15
- 15
Article Description
Background: Deep venous thrombosis (DVT) is associated with severe morbidity and mortality in cancer. Mean platelet volume (MPV) is an indicator of activated platelets. Objective: We aimed to investigate whether the combination of D-dimer and MPV could have a better performance in predicting deep venous thrombosis (DVT) in patients with breast cancer. MEHTODS: In 342 consecutive breast cancer patients without preoperative DVT, we measured the preoperative D-dimer and MPV levels. Compression ultrasonography was performed in all breast cancer patients before surgery, as well as one month, three months, six months, and twelve months. Results: During a median period of twelve months, 15 of the 234 patients (6.4%) developed DVT. MPV was reduced and D-dimer was increased in patients with DVT events compared to those without DVT. Multivariate Cox analysis revealed that both MPV and D-dimer were independent predictors for DVT events. The area under the ROC curve was 0.619 (95% CI: 0.553 to 0.681) when D-dimer was used alone, whereas it increased to 0.790 (95% CI 0.732 to 0.840, p < 0.001) with the addition of MPV. Conclusions: The combination of preoperative D-Dimer and MPV improves the predictive power of postoperative DVT risk in breast cancer patients.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85044367585&origin=inward; http://dx.doi.org/10.3233/cbm-170975; http://www.ncbi.nlm.nih.gov/pubmed/29278886; https://journals.sagepub.com/doi/full/10.3233/CBM-170975; http://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/CBM-170975; https://dx.doi.org/10.3233/cbm-170975; https://content.iospress.com:443/articles/cancer-biomarkers/cbm170975
SAGE Publications
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