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Older candidates for subthalamic deep brain stimulation in Parkinson's disease have a higher incidence of psychiatric serious adverse events

Frontiers in Aging Neuroscience, ISSN: 1663-4365, Vol: 8, Issue: JUN, Page: 132
2016
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Article Description

Objective: To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD). Methods: We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups. Results: A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (p < 0.01). Conclusions: The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects.

Bibliographic Details

Cozac, Vitalii V; Ehrensperger, Michael M; Gschwandtner, Ute; Hatz, Florian; Meyer, Antonia; Monsch, Andreas U; Schuepbach, Michael; Taub, Ethan; Fuhr, Peter

Frontiers Media SA

Biochemistry, Genetics and Molecular Biology; Neuroscience

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