Older candidates for subthalamic deep brain stimulation in Parkinson's disease have a higher incidence of psychiatric serious adverse events
Frontiers in Aging Neuroscience, ISSN: 1663-4365, Vol: 8, Issue: JUN, Page: 132
2016
- 16Citations
- 71Captures
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Metrics Details
- Citations16
- Citation Indexes16
- 16
- CrossRef2
- Captures71
- Readers71
- 71
Article Description
Objective: To investigate the incidence of serious adverse events (SAE) of subthalamic deep brain stimulation (STN-DBS) in elderly patients with Parkinson's disease (PD). Methods: We investigated a group of 26 patients with PD who underwent STN-DBS at mean age 63.2 ± 3.3 years. The operated patients from the EARLYSTIM study (mean age 52.9 ± 6.6) were used as a comparison group. Incidences of SAE were compared between these groups. Results: A higher incidence of psychosis and hallucinations was found in these elderly patients compared to the younger patients in the EARLYSTIM study (p < 0.01). Conclusions: The higher incidence of STN-DBS-related psychiatric complications underscores the need for comprehensive psychiatric pre- and postoperative assessment in older DBS candidates. However, these psychiatric SAE were transient, and the benefits of DBS clearly outweighed its adverse effects.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84980325888&origin=inward; http://dx.doi.org/10.3389/fnagi.2016.00132; http://www.ncbi.nlm.nih.gov/pubmed/27375478; http://journal.frontiersin.org/Article/10.3389/fnagi.2016.00132/abstract; https://dx.doi.org/10.3389/fnagi.2016.00132; https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2016.00132/full
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