PlumX Metrics
Embed PlumX Metrics

Untangling the Manganese-α-Synuclein Web

Frontiers in Neuroscience, ISSN: 1662-453X, Vol: 10, Issue: AUG, Page: 364
2016
  • 35
    Citations
  • 0
    Usage
  • 46
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Most Recent News

Untangling the Manganese-α-Synuclein Web.

Front Neurosci. 2016;10:364. Epub 2016 Aug 4 Authors: Peres TV, Parmalee NL, Martinez-Finley EJ, Aschner M PubMed: 27540354 Submit Comment

Review Description

Neurodegenerative diseases affect a significant portion of the aging population. Several lines of evidence suggest a positive association between environmental exposures, which are common and cumulative in a lifetime, and development of neurodegenerative diseases. Environmental or occupational exposure to manganese (Mn) has been implicated in neurodegeneration due to its ability to induce mitochondrial dysfunction, oxidative stress, and a-synuclein (α-Syn) aggregation. The role of the α-Syn protein vis-a-vis Mn is controversial, as it seemingly plays a duplicitous role in neuroprotection and neurodegeneration. α-Syn has low affinity for Mn, however an indirect interaction cannot be ruled out. In this review we will examine the current knowledge surrounding the interaction of α-Syn and Mn in neurodegenerative process.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know