Numb isoforms deregulation in medulloblastoma and role of p66 isoform in cancer and neural stem cells
Frontiers in Pediatrics, ISSN: 2296-2360, Vol: 6, Page: 315
2018
- 11Citations
- 13Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations11
- Citation Indexes11
- 10
- Captures13
- Readers13
- 13
Article Description
Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal expression has been described in several types of cancer. Involvement of deregulated Numb expression has been described in the malignant childhood brain tumor medulloblastoma, while Numb isoforms in these tumors and in cancer stem-like cells derived from them, have not been studied to date. Here we show that medulloblastoma stem-like cells and cerebellar neuronal stem cells (NSCs) express Numb p66 where its expression tampers stemness features. Furthermore, medulloblastoma samples evaluated in this study express decreased levels of Numb p66 while overexpressed Numb p72 compared with normal tissues. Our results uncover different roles for the two major Numb isoforms examined in medulloblastoma and a critical role for Numb p66 in regulating stem-like cells and NSCs maintenance.
Bibliographic Details
10.3389/fped.2018.00315; 10.3389/fped.2018.00315.s003; 10.3389/fped.2018.00315.s005; 10.3389/fped.2018.00315.s008; 10.3389/fped.2018.00315.s007; 10.3389/fped.2018.00315.s010; 10.3389/fped.2018.00315.s009; 10.3389/fped.2018.00315.s004; 10.3389/fped.2018.00315.s006; 10.3389/fped.2018.00315.s001; 10.3389/fped.2018.00315.s002
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85057200346&origin=inward; http://dx.doi.org/10.3389/fped.2018.00315; http://www.ncbi.nlm.nih.gov/pubmed/30443541; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s003; http://dx.doi.org/10.3389/fped.2018.00315.s003; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s005; http://dx.doi.org/10.3389/fped.2018.00315.s005; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s008; http://dx.doi.org/10.3389/fped.2018.00315.s008; https://www.frontiersin.org/article/10.3389/fped.2018.00315/full; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s007; http://dx.doi.org/10.3389/fped.2018.00315.s007; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s010; http://dx.doi.org/10.3389/fped.2018.00315.s010; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s009; http://dx.doi.org/10.3389/fped.2018.00315.s009; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s004; http://dx.doi.org/10.3389/fped.2018.00315.s004; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s006; http://dx.doi.org/10.3389/fped.2018.00315.s006; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s001; http://dx.doi.org/10.3389/fped.2018.00315.s001; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s002; http://dx.doi.org/10.3389/fped.2018.00315.s002; https://dx.doi.org/10.3389/fped.2018.00315; https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2018.00315/full; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/full; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/pdf
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