PlumX Metrics
Embed PlumX Metrics

Numb isoforms deregulation in medulloblastoma and role of p66 isoform in cancer and neural stem cells

Frontiers in Pediatrics, ISSN: 2296-2360, Vol: 6, Page: 315
2018
  • 11
    Citations
  • 0
    Usage
  • 13
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal expression has been described in several types of cancer. Involvement of deregulated Numb expression has been described in the malignant childhood brain tumor medulloblastoma, while Numb isoforms in these tumors and in cancer stem-like cells derived from them, have not been studied to date. Here we show that medulloblastoma stem-like cells and cerebellar neuronal stem cells (NSCs) express Numb p66 where its expression tampers stemness features. Furthermore, medulloblastoma samples evaluated in this study express decreased levels of Numb p66 while overexpressed Numb p72 compared with normal tissues. Our results uncover different roles for the two major Numb isoforms examined in medulloblastoma and a critical role for Numb p66 in regulating stem-like cells and NSCs maintenance.

Bibliographic Details

http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85057200346&origin=inward; http://dx.doi.org/10.3389/fped.2018.00315; http://www.ncbi.nlm.nih.gov/pubmed/30443541; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s003; http://dx.doi.org/10.3389/fped.2018.00315.s003; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s005; http://dx.doi.org/10.3389/fped.2018.00315.s005; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s008; http://dx.doi.org/10.3389/fped.2018.00315.s008; https://www.frontiersin.org/article/10.3389/fped.2018.00315/full; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s007; http://dx.doi.org/10.3389/fped.2018.00315.s007; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s010; http://dx.doi.org/10.3389/fped.2018.00315.s010; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s009; http://dx.doi.org/10.3389/fped.2018.00315.s009; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s004; http://dx.doi.org/10.3389/fped.2018.00315.s004; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s006; http://dx.doi.org/10.3389/fped.2018.00315.s006; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s001; http://dx.doi.org/10.3389/fped.2018.00315.s001; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/supplementary-material/10.3389/fped.2018.00315.s002; http://dx.doi.org/10.3389/fped.2018.00315.s002; https://dx.doi.org/10.3389/fped.2018.00315; https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2018.00315/full; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/full; https://www.frontiersin.org/articles/10.3389/fped.2018.00315/pdf

Abballe, Luana; Mastronuzzi, Angela; Miele, Evelina; Carai, Andrea; Besharat, Zein Mersini; Moretti, Marta; De Smaele, Enrico; Giangaspero, Felice; Locatelli, Franco; Ferretti, Elisabetta; Po, Agnese

Frontiers Media SA

Medicine

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know