Kaempferol, a Major Flavonoid in Ginkgo Folium, Potentiates Angiogenic Functions in Cultured Endothelial Cells by Binding to Vascular Endothelial Growth Factor
Frontiers in Pharmacology, ISSN: 1663-9812, Vol: 11, Page: 526
2020
- 40Citations
- 32Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations40
- Citation Indexes40
- 40
- CrossRef1
- Captures32
- Readers32
- 32
Article Description
Kaempferol is a major flavonoid in Ginkgo Folium and other edible plants, which is being proposed here to have roles in angiogenesis. Angiogenesis is important in both physiological and pathological development. Here, kaempferol was shown to bind with vascular endothelial growth factor (VEGF), probably in the heparin binding domain of VEGF: this binding potentiated the angiogenic functions of VEGF in various culture models. Kaempferol potentiated the VEGF-induced cell motility in human umbilical vein endothelial cells (HUVECs), as well as the sub-intestinal vessel sprouting in zebrafish embryos and formation of microvascular in rat aortic ring. In cultured HUVECs, application of kaempferol strongly potentiated the VEGF-induced phosphorylations of VEGFR2, endothelial nitric oxide synthase (eNOS) and extracellular signal-regulated kinase (Erk) in time-dependent and concentration-dependent manners, and in parallel the VEGF-mediated expressions of matrix metalloproteinases (MMPs), MMP-2 and MMP-9, were significantly enhanced. In addition, the potentiation effect of kaempferol was revealed in VEGF-induced migration of skin cell and monocyte. Taken together, our results suggested the pharmacological roles of kaempferol in potentiating VEGF-mediated functions should be considered.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85084577281&origin=inward; http://dx.doi.org/10.3389/fphar.2020.00526; http://www.ncbi.nlm.nih.gov/pubmed/32410995; https://www.frontiersin.org/articles/10.3389/fphar.2020.00526/supplementary-material/10.3389/fphar.2020.00526.s001; http://dx.doi.org/10.3389/fphar.2020.00526.s001; https://www.frontiersin.org/article/10.3389/fphar.2020.00526/full; https://dx.doi.org/10.3389/fphar.2020.00526.s001; https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.00526/full; https://dx.doi.org/10.3389/fphar.2020.00526
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