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Notch Signaling and PD-1/PD-L1 Interaction in Hepatocellular Carcinoma: Potentialities of Combined Therapies

Biomolecules, ISSN: 2218-273X, Vol: 14, Issue: 12
2024
  • 0
    Citations
  • 0
    Usage
  • 0
    Captures
  • 1
    Mentions
  • 8
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Mentions
    1
    • News Mentions
      1
      • News
        1
  • Social Media
    8
    • Shares, Likes & Comments
      8
      • Facebook
        8

Most Recent News

Data on Liver Cancer Reported by a Researcher at University of Bologna (Notch Signaling and PD-1/PD-L1 Interaction in Hepatocellular Carcinoma: Potentialities of Combined Therapies)

2024 DEC 26 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Daily -- A new study on liver cancer is now available. According

Review Description

Immunotherapy has shown significant improvement in the survival of patients with hepatocellular carcinoma (HCC) compared to TKIs as first-line treatment. Unfortunately, approximately 30% of HCC exhibits intrinsic resistance to ICIs, making new therapeutic combinations urgently needed. The dysregulation of the Notch signaling pathway observed in HCC can affect immune cell response, reducing the efficacy of cancer immunotherapy. Here, we provide an overview of how Notch signaling regulates immune responses and present the therapeutic rationale for combining Notch signaling inhibition with ICIs to improve HCC treatment. Moreover, we propose using exosomes as non-invasive tools to assess Notch signaling activation in hepatic cancer cells, enabling accurate stratification of patients who can benefit from combined strategies.

Bibliographic Details

Annapaola Montagner; Andrea Arleo; Fabrizia Suzzi; Fabio Piscaglia; Catia Giovannini; Antonino B. D’Assoro; Laura Gramantieri

MDPI AG

Biochemistry, Genetics and Molecular Biology

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