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Bioprocess intensification using flow reactors: Stereoselective oxidation of achiral 1,3-diols with immobilized Acetobacter aceti

Catalysts, ISSN: 2073-4344, Vol: 9, Issue: 3
2019
  • 23
    Citations
  • 0
    Usage
  • 43
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    23
    • Citation Indexes
      23
  • Captures
    43

Article Description

Enantiomerically enriched 2-hydroxymethylalkanoic acids were prepared by oxidative desymmetrisation of achiral 1,3-diols using immobilized cells of Acetobacter aceti in water at 28C. The biotransformations were first performed in batch mode with cells immobilized in dry alginate, furnishing the desired products with high molar conversion and reaction times ranging from 2 to 6 h. The biocatalytic process was intensified using a multiphasic flow reactor, where a segmented gas–liquid flow regime was applied for achieving an efficient O-liquid transfer; the continuous flow systems allowed for high yields and high biocatalyst productivity.

Bibliographic Details

Valerio De Vitis; Diego Romano; Francesco Molinari; Federica Dall’oglio; Lucia Tamborini; Francesca Tentori; Elisabetta Brenna; Martina Letizia Contente

MDPI AG

Chemical Engineering; Chemistry

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