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Epithelioid Fibrous Histiocytoma with Fusion: First Case Report.

Dermatopathology (Basel, Switzerland), ISSN: 2296-3529, Vol: 10, Issue: 1, Page: 25-29
2023
  • 2
    Citations
  • 0
    Usage
  • 1
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    2
    • Citation Indexes
      2
      • CrossRef
        2
  • Captures
    1

Article Description

Epithelioid fibrous histiocytoma (EFH) is a type of uncommon skin tumor mostly harboring Anaplastic Lymphoma Kinase () gene rearrangement, with different fusion partners reported. Whether this tumor is a separate entity or has a relationship with conventional fibrous histiocytomas is still a matter of debate. Benign course is the rule after complete surgical excision. A rare subtype of EFH with fusiform cells has been described, with specific fusion partners. Inflammatory myofibroblastic tumor (IMT) is a type of soft tissue tumor rarer than EFH, and it can display distant metastases. Some cases of primary cutaneous IMT included two with Cysteinyl-tRNA Synthetase 1 ()- rearrangement. IMT can have the same fusion partners as EFH, such as , or genes. We report the case of a 42-year-old woman presenting EFH with fusiform morphology harboring fusion and discuss similarities and differences with IMT.

Bibliographic Details

Secco, Léo-Paul; Libbrecht, Louis; Seijnhaeve, Elsa; Eggers, Silke; Dekairelle, Anne-France; De Roo, An-Katrien

MDPI AG

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