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The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key

International Journal of Molecular Sciences, ISSN: 1422-0067, Vol: 25, Issue: 15
2024
  • 0
    Citations
  • 0
    Usage
  • 7
    Captures
  • 2
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Captures
    7
  • Mentions
    2
    • Blog Mentions
      1
      • Blog
        1
    • News Mentions
      1
      • News
        1

Most Recent News

Reports Summarize Kawasaki Disease Research from National University of Singapore (The Future of Kawasaki Disease Diagnosis: Liquid Biopsy May Hold the Key)

2024 AUG 14 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Cardiovascular Daily -- New study results on Kawasaki disease have been published.

Review Description

Kawasaki disease (KD) is a febrile illness characterised by systemic inflammation of small- and medium-sized blood vessels, which commonly occurs in young children. Although self-limiting, there is a risk of developing coronary artery lesions as the disease progresses, with delay in diagnosis and treatment. Unfortunately, the diagnosis of KD continues to remain a clinical dilemma. Thus, this article not only summarises the key research gaps associated with KD, but also evaluates the possibility of using circulating endothelial injury biomarkers, such as circulating endothelial cells, endothelial microparticles and vascular endothelial cell-free DNA, as diagnostic and prognostic tools for KD: a “liquid biopsy” approach. The challenges of translating liquid biopsies to use in KD and the opportunities for improvement in its diagnosis and management that such translation may provide are discussed. The use of endothelial damage markers, which are easily obtained via blood collection, as diagnostic tools is promising, and we hope this will be translated to clinical applications in the near future.

Bibliographic Details

Markandran, Kasturi; Clemente, Kristine Nicole Mendoza; Tan, Elena; Attal, Karan; Chee, Qiao Zhi; Cheung, Christine; Chen, Ching Kit

MDPI AG

Chemical Engineering; Biochemistry, Genetics and Molecular Biology; Chemistry; Computer Science

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