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A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl) quinolines from morita-baylis-hillman adducts and their oxidation to the corresponding sulfones

Molecules, ISSN: 1420-3049, Vol: 17, Issue: 5, Page: 5081-5094
2012
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Article Description

A convenient one-pot preparation of 2-methyl-3-(phenylthiomethyl)quinolines from Morita-Baylis-Hillman adducts via conjugate addition of thiols followed by reductive cyclization with Fe/AcOH was developed. The 2-methyl-3- (phenylthiomethyl)quinolines were transformed into 2-methyl-3- (phenylsulfonylmethyl)quinolines via m-CPBA-mediated oxidation © 2012 by the authors.

Bibliographic Details

Ramesh, Chintakunta; Lei, Po-Min; Kavala, Veerababurao; Kuo, Chun-Wei; Yao, Ching-Fa

MDPI AG

Chemistry; Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics

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