Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain.

Citation data:

International journal of molecular sciences, ISSN: 1422-0067, Vol: 18, Issue: 11, Page: 2438

Publication Year:
2017
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PMID:
29149026
DOI:
10.3390/ijms18112438
Author(s):
Clarke, Duncan J; Azuma, Yoshiaki
Publisher(s):
MDPI AG
Tags:
Chemical Engineering; Biochemistry, Genetics and Molecular Biology; Chemistry; Computer Science
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review description
DNA Topoisomerase IIα (Topo IIα) is a ubiquitous enzyme in eukaryotes that performs the strand passage reaction where a double helix of DNA is passed through a second double helix. This unique reaction is critical for numerous cellular processes. However, the enzyme also possesses a C-terminal domain (CTD) that is largely dispensable for the strand passage reaction but is nevertheless important for the fidelity of cell division. Recent studies have expanded our understanding of the roles of the Topo IIα CTD, in particular in mitotic mechanisms where the CTD is modified by Small Ubiquitin-like Modifier (SUMO), which in turn provides binding sites for key regulators of mitosis.