Prenatal Choline Supplementation Diminishes Early-Life Iron Deficiency-Induced Reprogramming of Molecular Networks Associated with Behavioral Abnormalities in the Adult Rat Hippocampus.

Citation data:

The Journal of nutrition, ISSN: 1541-6100, Vol: 146, Issue: 3, Page: 484-93

Publication Year:
2016
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PMID:
26865644
DOI:
10.3945/jn.115.227561
PMCID:
PMC4763487
Author(s):
Tran, Phu V; Kennedy, Bruce C; Pisansky, Marc T; Won, Kyoung-Jae; Gewirtz, Jonathan C; Simmons, Rebecca A; Georgieff, Michael K
Publisher(s):
Oxford University Press (OUP)
Tags:
Medicine; Nursing
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article description
Early-life iron deficiency is a common nutrient deficiency worldwide. Maternal iron deficiency increases the risk of schizophrenia and autism in the offspring. Postnatal iron deficiency in young children results in cognitive and socioemotional abnormalities in adulthood despite iron treatment. The rat model of diet-induced fetal-neonatal iron deficiency recapitulates the observed neurobehavioral deficits.