Management of chronic hepatitis B before and after liver transplantation
World Journal of Hepatology, ISSN: 1948-5182, Vol: 7, Issue: 10, Page: 1421-1426
2015
- 20Citations
- 15Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations20
- Citation Indexes20
- 20
- CrossRef16
- Captures15
- Readers15
- 15
- Mentions1
- News Mentions1
- News1
Most Recent News
Management of chronic hepatitis B before and after liver transplantation.
Authors: James Fung PMID: 26052387 DOI: 10.4254/wjh.v7.i10.1421 Publication Type: Review ISSN: 1948-5182 Journal Title: World journal of hepatology Publication Date: 2015 Jun 08 Abstract Liver
Article Description
Liver transplantation remains the only curative option for eligible patients with complications of chronic hepatitis B (CHB) infection, including severe acute hepatitis flares, decompensated cirrhosis, and hepatocellular carcinoma. In general, all patients with CHB awaiting liver transplantation should be treated with oral nucleos(t)ide analogs (NAs) with high barriers to resistance to prevent potential flares of hepatitis and reduce disease progression. After liver transplantation, lifelong antiviral therapy is also required to prevent graft hepatitis, which may lead to subsequent graft loss. Although combination therapy using NA and hepatitis B immune globulin (HBIG) has been the regimen most widely adopted for over a decade, recent studies have demonstrated that newer NAs with low rates of resistance are effective in preventing graft hepatitis even without the use of HBIG, achieving excellent long term outcome. For patients without pre-existing resistant mutations, monotherapy with a single NA has been shown to be effective. For those with resistant strains, a combination of nucleoside analog and nucleotide analog should be used. To date, clinical trials using therapeutic vaccination have shown suboptimal response, as CHB patients likely have an immune deficit against HBV epitopes. Future strategies include targeting different sites of the hepatitis B replication cycle and restoring the host immunity response to facilitate complete viral eradication.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84930386957&origin=inward; http://dx.doi.org/10.4254/wjh.v7.i10.1421; http://www.ncbi.nlm.nih.gov/pubmed/26052387; http://www.wjgnet.com/1948-5182/full/v7/i10/1421.htm; https://dx.doi.org/10.4254/wjh.v7.i10.1421; https://www.wjgnet.com/1948-5182/full/v7/i10/1421.htm
Baishideng Publishing Group Inc.
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