Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in vitro.

Citation data:

Journal of intercultural ethnopharmacology, ISSN: 2146-8397, Vol: 5, Issue: 2, Page: 122-30

Publication Year:
2016
Usage 7
Abstract Views 6
Clicks 1
Captures 20
Readers 20
Mentions 1
News Mentions 1
Social Media 7
Shares, Likes & Comments 7
Citations 11
Citation Indexes 11
PMID:
27104032
DOI:
10.5455/jice.20160321115402
PMCID:
PMC4835986
Author(s):
Irondi, Emmanuel Anyachukwu; Agboola, Samson Olalekan; Oboh, Ganiyu; Boligon, Aline Augusti; Athayde, Margareth Linde; Shode, Francis O
Publisher(s):
ScopeMed International Medical Journal Management and Indexing System
Tags:
Pharmacology, Toxicology and Pharmaceutics; Medicine
Most Recent News Mention
article description
Elevated uric acid level, an index of gout resulting from the over-activity of xanthine oxidase (XO), increases the risk of developing hypertension. However, research has shown that plant-derived inhibitors of XO and angiotensin 1-converting enzyme (ACE), two enzymes implicated in gout and hypertension, respectively, can prevent or ameliorate both diseases, without noticeable side effects. Hence, this study characterized the polyphenolics composition of guava leaves extract and evaluated its inhibitory effect on XO and ACE in vitro.