Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors
eLife, ISSN: 2050-084X, Vol: 7
2018
- 57Citations
- 124Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations57
- Citation Indexes57
- 40
- CrossRef39
- Captures124
- Readers124
- 124
Article Description
Dopamine (DA) neurons of the ventral tegmental area (VTA) integrate cholinergic inputs to regulate key functions such as motivation and goal-directed behaviors. Yet the temporal dynamic range and mechanism of action of acetylcholine (ACh) on the modulation of VTA circuits and reward-related behaviors are not known. Here, we used a chemical-genetic approach for rapid and precise optical manipulation of nicotinic neurotransmission in VTA neurons in living mice. We provide direct evidence that the ACh tone fine-tunes the firing properties of VTA DA neurons through β2-containing (β2*) nicotinic ACh receptors (nAChRs). Furthermore, locally photo-antagonizing these receptors in the VTA was sufficient to reversibly switch nicotine reinforcement on and off. By enabling control of nicotinic transmission in targeted brain circuits, this technology will help unravel the various physiological functions of nAChRs and may assist in the design of novel therapies relevant to neuropsychiatric disorders.
Bibliographic Details
10.7554/elife.37487; 10.7554/elife.37487.001; 10.7554/elife.37487.012; 10.7554/elife.37487.003; 10.7554/elife.37487.002; 10.7554/elife.37487.005; 10.7554/elife.37487.015; 10.7554/elife.37487.009
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85058369358&origin=inward; http://dx.doi.org/10.7554/elife.37487; http://www.ncbi.nlm.nih.gov/pubmed/30176987; https://elifesciences.org/articles/37487#abstract; http://dx.doi.org/10.7554/elife.37487.001; https://elifesciences.org/articles/37487; https://elifesciences.org/articles/37487#fig4; http://dx.doi.org/10.7554/elife.37487.012; https://elifesciences.org/articles/37487#fig1; http://dx.doi.org/10.7554/elife.37487.003; https://elifesciences.org/articles/37487#digest; http://dx.doi.org/10.7554/elife.37487.002; https://elifesciences.org/articles/37487#fig2; http://dx.doi.org/10.7554/elife.37487.005; https://elifesciences.org/articles/37487#fig5; http://dx.doi.org/10.7554/elife.37487.015; https://elifesciences.org/articles/37487#fig3; http://dx.doi.org/10.7554/elife.37487.009; https://dx.doi.org/10.7554/elife.37487
eLife Sciences Publications, Ltd
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