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Regulation of the heat stress response in arabidopsis by MPK6-targeted phosphorylation of the heat stress factor HsfA2

PeerJ, ISSN: 2167-8359, Vol: 2013, Issue: 1, Page: e59
2013
  • 101
    Citations
  • 0
    Usage
  • 115
    Captures
  • 0
    Mentions
  • 16
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    101
  • Captures
    115
  • Social Media
    16
    • Shares, Likes & Comments
      16
      • Facebook
        16

Article Description

So far little is known on the functional role of phosphorylation in the heat stress response of plants. Here we present evidence that heat stress activates the Arabidopsis mitogen-activated protein kinase MPK6. In vitro and in vivo evidence is provided that MPK6 specifically targets the major heat stress transcription factor HsfA2. Activation of MPK6 results in complex formation with HsfA2. MPK6 phosphory- lates HsfA2 on T249 and changes its intracellular localisation. Protein kinase and phosphatase inhibitor studies indicate that HsfA2 protein stability is regulated in a phosphorylation-dependent manner, but this mechanism is independent of MPK6. Overall, our data show that heat stress-induced targeting of HsfA2 by MPK6 partici- pates in the complex regulatory mechanism how plants respond to heat stress. © 2013 Evrard et al.

Bibliographic Details

Evrard, Alexandre; Kumar, Mukesh; Lecourieux, David; Lucks, Jessica; von Koskull-Döring, Pascal; Hirt, Heribert

PeerJ

Neuroscience; Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences

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