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Involvement of Fas/FasL system in the pathogenesis of autoimmune diseases and Wilson's disease

Archivum Immunologiae et Therapiae Experimentalis, ISSN: 0004-069X, Vol: 47, Issue: 3, Page: 129-133
1999
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Article Description

The interaction of Fas with FasL has been demonstrated to be implicated in the pathogenesis of several autoimmune and liver diseases. Recently, attention has been focused on the hypothesis that thyrocytes and β cells undergo massive Fas/FasL-mediated apoptosis during autoimmune response. Similarly, hepatocyte cell death occurring following copper accumulation points towards the same mechanism.

Bibliographic Details

Giorgio Stassi; Valentina Di Felice; Matilde Todaro; Francesco Cappello; Giovanni Zummo; Felicia Farina; Ruggero De Maria; Massimo Trucco

Medicine; Immunology and Microbiology

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