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Bortezomib with or without dexamethasone in relapsed multiple myeloma following allogeneic hematopoietic cell transplantation

Haematologica, ISSN: 0390-6078, Vol: 91, Issue: 6, Page: 837-839
2006
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Article Description

We retrospectively evaluated the efficacy of bortezomib in 23 patients with multiple myeloma who had relapsed after allografting. Bortezomib was given as single agent to 9 patients (39%) and in combination with steroids in the other 14 (61%). Major toxicities were thrombocytopenia (10/23, 43%) and peripheral neuropathy (12/23, 52%). The overall response rate was 61% (14/23), including 22% (5/23) immunofixation-negative complete remissions. No significant differences in toxicity and response rates were seen between patients treated with bortezomib plus steroids and bortezomib alone. After a median follow-up of 6 months, progression free survival was 6 months. Twenty-one patients are alive, two and five in continuous very good partial and complete remissions, respectively. ©2006 Ferrata Storti Foundation.

Bibliographic Details

Bruno, Benedetto; Patriarca, Francesca; Sorasio, Roberto; Mattei, Daniele; Montefusco, Vittorio; Peccatori, Jacopo; Bonifazi, Francesca; Petrucci, Maria Teresa; Milone, Giuseppe; Guidi, Stefano; Giaccone, Luisa; Rotta, Marcello; Fanin, Renato; Boccadoro, Mario; Corradini, Paolo; Gruppo Italiano Trapianti di Midollo

Medicine

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