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Designing novel pH-sensitive non-phospholipid vesicle: Characterization and cell interaction

European Journal of Pharmaceutical Sciences, ISSN: 0928-0987, Vol: 28, Issue: 5, Page: 385-393
2006
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Article Description

In this work, we report the preparation, the characterization and interaction with cells of novel pH-sensitive non-phospholipid vesicle formulations, from a non-ionic surfactant mixed with cholesterol (CHOL) and his derivative cholesteryl hemisuccinate (CHEMS), as pH-sensitive molecule. This molecule, can destabilize the vesicle lipid bilayer when exposed to an acidic environment, with a subsequent release of vesicular content, enhancing the cytoplasmatic delivery of drugs to target cells.

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