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Statins-mediated inhibition of Rho GTPases as a potential tool in anti-tumor therapy

Mini-Reviews in Medicinal Chemistry, ISSN: 1389-5575, Vol: 8, Issue: 6, Page: 609-618
2008
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Review Description

Rho GTPases, which control processes such as cell proliferation and cytoskelelon remodeling, are often hyper-expressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy. © 2008 Bentham Science Publishers Ltd.

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