Enhanced antiviral activity of Acyclovir loaded into β-cyclodextrin-poly(4-acryloylmorpholine) conjugate nanoparticles
Journal of Controlled Release, ISSN: 0168-3659, Vol: 137, Issue: 2, Page: 116-122
2009
- 83Citations
- 89Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations83
- Citation Indexes83
- 83
- CrossRef68
- Captures89
- Readers89
- 89
Article Description
Novel polymeric nanoparticles based on a β-cyclodextrin-poly(4-acryloylmorpholine) mono-conjugate (β-CD-PACM), a tadpole-shaped polymer in which the β-CD ring is the hydrophilic head and the PACM chain the amphiphilic tail, were prepared by the solvent injection technique. Acyclovir-loaded nanoparticles were prepared from inclusion complexes of Acyclovir with β-CD-PACM. Both unloaded and drug-loaded nanoparticles were characterized in terms of particle size distribution, morphology, zeta potential, drug loading and in vitro drug release rate. The antiviral activity of Acyclovir loaded into β-CD-PACM nanoparticles against two clinical isolates of HSV-1 was evaluated and found to be remarkably superior compared with that of both the free drug and a soluble β-CD-PACM complex reported in a previous paper. Fluorescent nanoparticles loaded with coumarin 6 were also prepared in order to investigate the nanoparticle cell uptake by confocal laser microscopy. It was found that the nanoparticles are internalized in cells and locate in the perinuclear compartment.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0168365909002181; http://dx.doi.org/10.1016/j.jconrel.2009.04.004; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67349085245&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/19361545; https://linkinghub.elsevier.com/retrieve/pii/S0168365909002181; https://dx.doi.org/10.1016/j.jconrel.2009.04.004
Elsevier BV
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